Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。
| 生物活性 | Indimitecan (LMP776) is atopoisomeraseI (Top1) inhibitor with anticancer activities[1]. |
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体外研究
(In Vitro) | Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM[1].
Indimitecan shows potent DNA cleavage due to Top1 inhibition[1].
Indimitecan can be substrates for metabolic ketone reductases[1].
Cell Proliferation Assay[1] | Cell Line: | HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7 | | Concentration: | 0-100 μM | | Incubation Time: | | | Result: | Showed growth inhibition with GI50s of<0.01,<0.01, 0.04,<0.01, 0.08,<0.01,<0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : 8.33 mg/mL(18.13 mM;ultrasonic and warming and adjust pH to 3 with HCl and heat to 60℃) 配制储备液 | 1 mM | 2.1765 mL | 10.8826 mL | 21.7652 mL | | 5 mM | 0.4353 mL | 2.1765 mL | 4.3530 mL | | 10 mM | 0.2177 mL | 1.0883 mL | 2.1765 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
