Semaglutide TFA, a long-actingGLP-1analogue, is a glucagon-like peptide-1(GLP-1)receptor agonist. Semaglutide TFA has the potential for type 2 diabetes treatment.

GLP-1 receptor^[1].

Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib⁸, Arg³⁴) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM^[1]. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1^[3.

The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs^[1]. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to liraglutide in most parameters^[2]. Semaglutide lowers blood glucose by stimulating the release of insulin and also lowers body weight^[3].

4227.66

Solid

C₁₈₉H₂₉₂F₃N₄₅O₆₁

索马鲁肽三氟乙酸

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 100 mg/mL(23.65 mM;ultrasonic and warming and heat to 60℃)

H₂O : 100 mg/mL(23.65 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。