Cinnamtannin A2

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Cinnamtannin A2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

86631-38-1

肉桂鞣质A2

Cinnamtannin A2 是一种四聚体原花青素，可以增加小鼠的 GLP-1 和胰岛素分泌。Cinnamtannin A2 可以上调促肾上腺皮质激素释放激素的表达。Cinnamtannin A2 具有抗氧化，抗糖尿病和肾保护作用。

生物活性

Cinnamtannin A2, a tetrameric procyanidin, can increasesGLP-1andinsulinsecretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect^[1]^[2].

体外研究
(In Vitro)

Cinnamtannin A2 (0.125-2.0 μg/mL) inhibits LDL oxidation induced by copper ions or MeO-AMVN^[3].

体内研究
(In Vivo)

Cinnamtannin A2 (10 mg/kg; i.p. for 30 days) ameliorates the level of KIM1 and NAGL in 5/6 nephractomized rats by regulating Nrf2- Keap1 pathway^[2].
Cinnamtannin A2 (10 μg/kg; p.o.) increases the secretion of insulin and glucagon-like peptide-1 (GLP-1) in plasma of mice^[1].
Cinnamtannin A2 (10 μg/kg; p.o.) significantly promotes phosphorylation of both IRB and IRS-1 in mice^[1].

Animal Model:	Male Sprague-Dawley rats (250-300 g) were induced chronic renal failure (CRF) by removing the kidneys^[2]
Dosage:	10 mg/kg
Administration:	I.p. for 30 days
Result:	Ameliorated the altered level of creatinine, blood urea nitrogen, Neutrophil gelatinase-associated lipocalin, Kidney Injury Molecule-1 and cytokines in the serum and microalbuminurea. Reduced the oxidative stress level. Attenuated the altered expression of proteins involved in Nrf2-Keap1 pathway in the kidney tissue. Reduced the tubular injury score in the kidney tissue.

分子量

1155.02

Formula

C₆₀H₅₀O₂₄

CAS 号

86631-38-1

中文名称

肉桂鞣质A2

结构分类

Flavonoids
Flavanonols

Flavonoids
Biflavones

Phenols
Polyphenols

来源

Plants
Lauraceae
Cinnamomum cassiaPresl

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.