Heraclenin，是一种天然呋喃香豆素，可从 Prangos pabularia 根部分离出来。Heraclenin 通过靶向激活的 T 细胞核因子 (NFAT) 来抑制人原代 T 细胞中 T 细胞受体介导的增殖，这种作用存在浓度依赖性。
| Cas No. | 2880-49-1 |
| 别名 | 独活内酯 |
| Canonical SMILES | CC1(C)[C@H](O1)COC2=C(OC=C3)C3=CC(C=C4)=C2OC4=O |
| 分子式 | C16H14O5 |
| 分子量 | 286.28 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Heraclenin, a natural furanocoumarin, isolated from the root parts of the plant Prangos pabularia. Heraclenin significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT)[1].
NFAT[1] [1]. MÁrquez N, et al. Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT. Planta Med. 2004 Nov;70(11):1016-21. |
