Tanomastat (BAY 12-9566) 是一种口服生物可利用的非肽类联苯基质金属蛋白酶 (MMP) 抑制剂，具有 Zn 结合羧基。 MMP-2、MMP-3、MMP-9、MMP-13 的 Ki 值分别为 11、143、301 和 1470 nM。 Tanomastat 在几种实验性肿瘤模型中显示出抗侵袭和抗转移活性。
| Cas No. | 179545-77-8 |
| 别名 | (S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸,BAY 12-9566 |
| Canonical SMILES | ClC1=CC=C(C2=CC=C(C(C[C@@H](C(O)=O)CSC3=CC=CC=C3)=O)C=C2)C=C1 |
| 分子式 | C23H19ClO3S |
| 分子量 | 410.9 |
| 溶解度 | DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 25 mg/ml,Ethanol: 12 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tanomastat is an orally available, non-peptidic inhibitor of matrix metalloproteinase-2 (MMP-2), MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively). It is active in various animal models of tumor metastasis and has been used in a phase III clinical trial in pancreatic, SCLC, NSCLC, and ovarian cancer patients. |
