SAICAR 是从头嘌呤核苷酸生物合成的中间体，以同工酶选择性方式激活丙酮酸激酶异构体 M2 (PKM2)，EC50 为 0.3 mM。 SAICAR 在葡萄糖受限的条件下刺激 PKM2 并促进癌细胞存活。
| Cas No. | 3031-95-6 |
| 别名 | Succino-AICAR |
| 化学名 | N-[[5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl]-L-aspartic acid |
| Canonical SMILES | NC1=C(C(N[C@H](C(O)=O)CC(O)=O)=O)N=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O2 |
| 分子式 | C13H19N4O12P |
| 分子量 | 454.3 |
| 溶解度 | Slightly soluble in methanol |
| 储存条件 | 4°C, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SAICAR is an intermediate in the de novo purine nucleotide synthesis pathway. It is reported to stimulate pyruvate kinase isoform M2 and to promote cancer cell survival in conditions of limited glucose availability.[1] Reference:
[1]. Keller, K.E., Tan, I.S., and Lee, Y.S. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science 338, 1069-1072 (2012). |
