(S)-Bromoenol lactone ((S)-BEL) 是一种不可逆的、手性的、基于机制的钙非依赖性磷脂酶 A2β (iPLA2β) 抑制剂，可抑制血管加压素诱导的培养的大鼠主动脉平滑肌 (A10) 释放花生四烯酸IC50 为 2 μM 的细胞。
| Cas No. | 478288-94-7 |
| 别名 | (S)-BEL; (S,E)-Bromoenol lactone |
| Canonical SMILES | Br/C=C1\CC[C@H](C(=O)O\1)c1cccc2ccccc12 |
| 分子式 | C16H13BrO2 |
| 分子量 | 317.2 |
| 溶解度 | DMF: 50 mg/ml,DMSO: 25 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): .05 mg/ml |
| 储存条件 | Store at -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM. (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ. |
