GW-803430

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GW-803430

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

515141-51-2

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

GW-3430

GW-803430 (GW-3430) 是一种有效的选择性黑色素浓缩激素受体 1 (MCH R1) 拮抗剂，pIC₅₀为 9.3。GW-803430 在肥胖动物模型中具有口服活性。

生物活性

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with apIC₅₀of 9.3. GW-803430 is orally active in an animal model of obesity^[1].

IC₅₀& Target

pIC50: 9.3 (MCH R1)^[1]

体外研究
(In Vitro)

GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC₅₀value of ~13 nM^[2].

体内研究
(In Vivo)

GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls^[1].
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t_1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice^[1].

Animal Model:	High fat diet-induced obese AKR/J mice^[1]
Dosage:	0.3, 3, and 15 mg/kg
Administration:	Orally, qd,12 days
Result:	Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.

分子量

481.99

性状

Solid

Formula

C₂₅H₂₄ClN₃O₃S

CAS 号

515141-51-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month