MTEP

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MTEP

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

329205-68-7

MTEP 是一种有效的、非竞争性和高选择性的mGluR5拮抗剂。MTEP 表现出抗抑郁和抗焦虑的作用。MTEP 可以用于帕金森疾病的研究。

生物活性

MTEP is a potent, non-competitive and highly selectivemGluR5antagonist, with anIC₅₀of 5 nM and aK_iof 16 nM. MTEP shows antidepressant and anxiolytic-like effects. MTEP can be used for Parkinson's disease research^[1]^[2]^[3]^[4].

IC₅₀& Target

mGluR5

5 nM (IC₅₀)

mGluR5

16 nM (Ki)

体外研究
(In Vitro)

MTEP 对 mGluR5 的选择性高于 mGluR1，对其他 mGluR 亚型没有影响，并且比 MPEP (HY-14609A) 有更少的脱靶效应^[1]。

体内研究
(In Vivo)

MTEP (0-5 mg/kg, 腹腔注射, 一次) 抑制由 Haloperidol (HY-14538) (0.5 mg/kg, 腹腔注射)诱导的僵直症^[2]。
MTEP (0.3-3 mg/kg, 腹腔注射, 一次) 在雄性 C57BL/6J 小鼠中诱导抗抑郁样作用^[3]。

Animal Model:	Male Wistar rats (215-315 g, 5-9/group)^[2]
Dosage:	1, 3 and 5 mg/kg
Administration:	IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)
Result:	Inhibited the catalepsy induced by Haloperidol (HY-14538).

Animal Model:	Male C57BL/6J mice (23-25 g)^[3]
Dosage:	0.3, 1 and 3 mg/kg
Administration:	IP, 1 h before the test
Result:	Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.

分子量

200.26

Formula

C₁₁H₈N₂S

CAS 号

329205-68-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.