(Thr4,Gly7)-Oxytocin, 一种催产素 (Oxytocin) 类似物，是一种特异性OT 受体激动剂。(Thr4,Gly7)-Oxytocin 还可通过激活 TRPV1 通道和抑制 K+通道来诱导眼下神经元兴奋。
| 生物活性 | (Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specificOT receptoragonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+channels.[1][2]. |
| IC50& Target | OT receptors, K+channels[1]. |
体外研究
(In Vitro) | (Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons[1].
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons[1].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells[2].
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels[2].
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体内研究
(In Vivo) | (Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1].
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3].
| Animal Model: | Swiss Webster mice[1] | | Dosage: | 1 μM | | Administration: | Intratracheal administration for 24 h | | Result: | Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons.
Increased the firing rate of TGOT-responsive PVT neurons in all subregions. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Sealed storage, away from moisture and light | Powder | -80°C | 2 years | | -20°C | 1 year |
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| 溶解性数据 | In Vitro: H2O : 100 mg/mL(106.37 mM;Need ultrasonic) 配制储备液 | 1 mM | 1.0637 mL | 5.3186 mL | 10.6372 mL | | 5 mM | 0.2127 mL | 1.0637 mL | 2.1274 mL | | 10 mM | 0.1064 mL | 0.5319 mL | 1.0637 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
