Sarolaner(PF-6450567)是一种可口服、广谱的杀外寄生虫剂，有效抑制狗身上的跳蚤和虱子，对C.felis的LC80值为0.3μg/mL，对O.turicata的LC100值为0.003μg/mL。
| Cas No. | 1398609-39-6 |
| 别名 | 1-[5'-[(5S)-5-(3,5-二氯-4-氟苯基)-4,5-二氢-5-(三氟甲基)-3-异恶唑基]螺[氮杂环丁烷-3,1'(3'H)-异苯并呋喃]-1-基]-2-(甲基磺酰基)乙酮,PF-6450567 |
| Canonical SMILES | O=S(CC(N1CC2(OCC3=C2C=CC(C4=NO[C@](C(F)(F)F)(C5=CC(Cl)=C(F)C(Cl)=C5)C4)=C3)C1)=O)(C)=O |
| 分子式 | C23H18Cl2F4N2O5S |
| 分子量 | 581.36 |
| 溶解度 | DMSO : 150 mg/mL (258.02 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at 4℃, sealed storage, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata[1].
LC80: 0.3μg/mL (C. felis)[1]LC100: 0.003 μg/mL (O. turicata)[1] [1]. McTier TL, et al. Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs. Vet Parasitol. 2016 May 30;222:3-11. |
