(+)-(3R,8S)-Falcarindiol是从胡萝卜中得到的聚乙炔，具有抗分歧杆菌(antimycobacterial)作用，对MycobacteriumtuberculosisH37Ra的最低抑制浓度MIC和IC50值分别为24μM和6μM。具有抗肿瘤和抗炎作用。
| Cas No. | 225110-25-8 |
| 别名 | 镰叶芹二醇,(3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol |
| Canonical SMILES | C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC |
| 分子式 | C17H24O2 |
| 分子量 | 260.37 |
| 溶解度 | Chloroform: soluble,DMSO: soluble,Ethanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC50 of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra[1][2]. Antineoplastic and anti-inflammatory activity[2].
IC50: 6 μM (Mycobacterium tuberculosis H37Ra)[1] [1]. O'Neill T, et al. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. J Ethnopharmacol. 2013 May 2;147(1):232-7.
[2]. Kobaek-Larsen M, et al. Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer. BMC Res Notes. 2018 Jun 27;11(1):411. |
