hGPR91 antagonist 1

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hGPR91 antagonist 1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1314796-00-3

HGPR91 antagonist 1 是一种有效的，选择性小分子hGPR91拮抗剂，IC₅₀为 7 μM。

生物活性

HGPR91 antagonist 1 is a potent and selective small moleculehGPR91antagonist with anIC₅₀of 7 μM^[1].

IC₅₀& Target

IC50: 7 μM (HGPR91)^[1]

体内研究
(In Vivo)

HGPR91 antagonist 1 leads to 59, 76% inhibition of ΔMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM^[1].

Animal Model:	Wistar rats^[1]
Dosage:	100 mg/kg
Administration:	I.p.; 2 and 4 hours
Result:	Led to 59 and 76% inhibition of ΔMAP at 2 and 4 hours.

分子量

529.53

性状

Solid

Formula

C₃₁H₂₃F₄N₃O

CAS 号

1314796-00-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 125 mg/mL(236.06 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.8885 mL	9.4423 mL	18.8847 mL
5 mM	0.3777 mL	1.8885 mL	3.7769 mL
10 mM	0.1888 mL	0.9442 mL	1.8885 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。