Argipressin acetate

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Argipressin acetate

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CAS NO:

129979-57-3

Arg8-vasopressin acetate
AVP acetate

Argipressin (Arg8-vasopressin) (acetate) 可与血管精氨酸加压素受体 V1、V2 和 V3结合，其在 A7r5 大鼠主动脉平滑肌细胞中对 V1 的K_d值为 1.31 nM。

生物活性

Argipressin (Arg8-vasopressin) (acetate) binds to theV1, V2, V3-vascular argininevasopressin receptor, with aK_dvalue of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1^[1]^[2]^[3]^[4].

体外研究
(In Vitro)

Argipressin (Arg8-vasopressin) (acetate) 在啮齿动物和人类 β 细胞中诱导增殖并阻止细胞因子诱导的细胞凋亡^[1]。

Cell Proliferation Assay^[1]

Cell Line:	clonal BRIN BD11 and 1.1B4 cells
Concentration:	10^-6M
Incubation Time:	2 h
Result:	Increased proliferation of rodent and human beta-cells.

Apoptosis Analysis^[1]

Cell Line:	clonal BRIN BD11 and 1.1B4 cells
Concentration:	10^-6M
Incubation Time:	2 h
Result:	Protected against cytokine-induced beta-cell apoptosis.

体内研究
(In Vivo)

Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; 腹腔内注射; 一次) 显著降低小鼠的总体 AUC 葡萄糖值，但不增加小鼠的胰岛素水平^[1]。

Animal Model:	NIH Swiss mice (adult; male; 12-14weeks)^[1]
Dosage:	25 nmol/kg bw
Administration:	AVP (25 nmol/kg bw; intraperitoneal injection; once)
Result:	Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.

分子量

1144.28

Formula

C48H69N15O14S2

CAS 号

129979-57-3

Sequence Shortening

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.