GNE-2256

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GNE-2256

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2102170-43-2

GNE-2256 (molecule 19) 是一种具有口服活性的IRAK4(白介素 1 受体关联激酶 4) 抑制剂 (IRAK4K_i=1.4 nM; IL-6IC₅₀=190 nM)。

生物活性

GNE-2256 (molecule 19) is an orally activeIRAK4(Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4K_i=1.4 nM;IL-6IC₅₀=190 nM)^[1].

IC₅₀& Target^[1]

IRAK4

1.4 nM (Ki)

体内研究
(In Vivo)

GNE-2256 (3 mg/kg) shows inhibition of IL-6, TNFα, and IFNα secretion in R848-induced mouse PD model^[1].

分子量

482.51

Formula

C₂₄H₂₇FN₆O₄

CAS 号

2102170-43-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.