MIF098

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MIF098

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1208448-95-6

MIF098 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂，可抑制肺平滑肌细胞增殖、迁移和纤维化。MIF098 可用于免疫炎症相关疾病研究。

生物活性

MIF098 is amacrophage migration inhibitory factor(MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research^[1].

体外研究
(In Vitro)

MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration in a concentration-dependent manner, by blocking the migration inhibitory factor (MIF) pathway^[1].
MIF098 reduces collagen synthesis and pulmonary artery fibrosis by inhibiting the TGFβ1/Smad2/3 pathway^[1].

Western Blot Analysis^[1]

Cell Line:	Mouse pulmonary artery smooth muscle cells (mPASMCs)
Concentration:	0-10 μM
Incubation Time:	48 hours
Result:	Reduced expression of cell cycle related proteins such as cyclin D1, CDK4 and CDK6 in PDGF-BB and increased expression of cell-cycle arrest proteins such as P53 and P21. Reduced TGFβ1-induced fibronectin (FN), collagen I (col I), and collagen II (col II) expression and phosphorylation of Smad2 and Smad3.

体内研究
(In Vivo)

MIF098 (intraperitoneal injection, 40 mg/kg, once a day, 4 weeks) attenuates the process of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice^[1].

Animal Model:	Hypoxic male C57BL/6J mice^[1]
Dosage:	40 mg/kg
Administration:	Intraperitoneal injection; once a day; 4 weeks
Result:	Reduced right ventricular systolic pressure (RVSP), percentage medial wall thickness, muscularization and right ventricle collagen deposition. Decreased percentage of collagen fibers in pulmonary artery (PA).

分子量

255.27

Formula

C₁₅H₁₃NO₃

CAS 号

1208448-95-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.