Dolasetron (MDL-73147)(MDL-73147) 是一种血清素 5-HT3 受体拮抗剂，用于治疗化疗后的恶心和呕吐。
| Cas No. | 115956-12-2 |
| 别名 | 多拉司琼,MDL-73147 |
| Canonical SMILES | O=C(C1=CNC2=C1C=CC=C2)O[C@@H]3C[C@@](CC4C5)([H])[N@](CC4=O)[C@@]5([H])C3 |
| 分子式 | C19H20N2O3 |
| 分子量 | 324.37 |
| 溶解度 | DMSO : ≥ 300 mg/mL (924.87 mM) |
| 储存条件 | Store at 2-8℃, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. [1]. Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7(1):50-8. [2]. Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV). Support Care Cancer. 2014 Feb;22(2):469-77. |
