| CAS NO: | 1636881-61-2 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 询价 |
| 2mg | 询价 |
| 5mg | 询价 |
| Cas No. | 1636881-61-2 |
| 别名 | AFQ-056 racemate |
| Canonical SMILES | CC1=CC(C#C[C@]2(O)CCC[C@]3([H])[C@@]2([H])CCN3C(OC)=O)=CC=C1.[relative stereochemistry] |
| 分子式 | C19H23NO3 |
| 分子量 | 313.39 |
| 溶解度 | DMSO : 50 mg/mL (159.55 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. For antagonistic activity, (-)-mavoglurant, the (-)-enantiomer shows IC50 of 0.11 μM and 0.03 μM (Ca2+ and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM[1]. [1]. Vranesic I, et al. AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorg Med Chem. 2014 Nov 1;22(21):5790-803 |
| 维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024 |