NFATc1-IN-1

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NFATc1-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1912422-56-0

NFATc1-IN-1 (compound A04) 一种是 RANKL- 诱导的破骨细胞 (osteoclast) 形成的有效抑制剂，其IC₅₀为 1.57 μM。NFATc1-IN-1 通过降低 RANKL 诱导的NFATc1核转位，显示抗破骨细胞 (anti-osteoclastogenic) 作用。NFATc1-IN-1 可用于破骨疾病的研究。

生物活性

NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-inducedosteoclastformation, with anIC₅₀of 1.57 μM. NFATc1-IN-1 showsanti-osteoclastogeniceffects through reducing the RANKL-induced nuclear translocation ofNFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research^[1].

体外研究
(In Vitro)

NFATc1-IN-1 (compound A04) (0-2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption^[1].
NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1^[1].

Cell Viability Assay^[1]

Cell Line:	Osteoclast precursor RAW 264.7 cells
Concentration:	0, 0.5, 1.0, 1.5, 2.0 and 2.5 μM
Incubation Time:	4 days
Result:	Markedly reduced the number and size of red TRAP-positive multinucleated osteoclasts at concentrations of 1.5, 2.0, and 2.5 μM. Significantly inhibited formation of osteoclasts in a dose-dependent manner (at 1.5, 2.0 and 2.5 μM), while showing no cytotoxic effects towards osteoclast precursor cells at concentrations of as high as 2.5 μM.

Immunofluorescence^[1]

Cell Line:	RAW264.7 cells
Concentration:	1.5 or 2.5 μM
Incubation Time:	24 h
Result:	Blocked NFATc1 nuclear translocation and decreased the level of NFATc1.

分子量

375.11

Formula

C₁₃H₈F₂INO₂

CAS 号

1912422-56-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.