Ergolide 是一种从大黄菊 (Inula Britannica) 的干燥花中分离出的倍半萜内酯。Ergolide 通过使 NF-κB 失活抑制 RAW 264.7 巨噬细胞中诱导的一氧化氮合酶和环加氧酶 2 的表达。
| Cas No. | 54999-07-4 |
| 别名 | 麦角内酯 |
| Canonical SMILES | CC(O[C@@H]1[C@]2([C@](CCC2=O)([H])[C@H](C)C[C@@](O3)([H])[C@@]1([H])C(C3=O)=C)C)=O |
| 分子式 | C17H22O5 |
| 分子量 | 306.35 |
| 溶解度 | DMSO: 50 mg/mL (163.21 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB[1]. [1]. Whan Han J, et al. Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB. Br J Pharmacol. 2001 Jun;133(4):503-12. |
