CTAP is a water soluble, cyclic octapeptide which acts as a receptor antagonist that is selective for the μ opioid receptor (IC50 = 3.5 nM) over the δ receptor (IC50 = 4,500 nM).
| Canonical SMILES | O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=C(C=C3)O)NC([C@@H](NC([C@@H](CC4=CC=CC=C4)N)=O)CSSC(C)([C@H](NC5=O)C(N[C@@H]([C@@H](C)O)C(N)=O)=O)C)=O)=O)N[C@@H](CCCNC(N)=N)C(N[C@H]5[C@@H](C)O)=O.FC(F)(C(O)=O)F |
| 分子式 | C51H69N13O11S2•XCF3COOH |
| 分子量 | 1104.3 |
| 溶解度 | Water: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CTAP is a water soluble, cyclic octapeptide which acts as a receptor antagonist that is selective for the µ opioid receptor (IC50 = 3.5 nM) over the δ receptor (IC50 = 4,500 nM). It is a poor antagonist of the somatostatin receptor (IC50 = 14.3 μM). CTAP is at least 10-fold more potent than naltrexone as an antagonist of diverse compounds which have antinociceptive effects through the µ opioid receptor. It resists enzymatic metabolism in the blood and enters the brain and cerebrospinal fluid. |
