DL-AP5 是一种 NMDA（N-甲基-D-天冬氨酸）受体拮抗剂。
| Cas No. | 76326-31-3 |
| 别名 | DL-2-氨基-5-膦酰基缬草酸,DL-2-Amino-5-Phosphonovaleric acid，2-APV |
| 化学名 | (R)-2-amino-5-phosphonopentanoic acid |
| Canonical SMILES | OP(O)(CCC[C@H](C(O)=O)N)=O |
| 分子式 | C5H12NO5P |
| 分子量 | 197.13 |
| 溶解度 | 10mg/mL in PBS, pH 7.2 |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5.[1] Whereas D-AP5 is the active (–)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 μM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.[1] AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.[2]
Reference:
[1]. Evans, R.H., Francis, A.A., Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br. J. Pharmacol. 75(1), 65-75 (1982).
[2]. Morris, R.J. Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9(9), 3040-3057 (1989). |
