HQL-79

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HQL-79

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

162641-16-9

HQL-79 是一种有效、选择性、可口服的人造血前列腺素 D 合成酶 (hematopoietic prostaglandin D synthase (H-PGDS)) 抑制剂，高度选择性地抑制 PGD₂的合成，为抗过敏剂，对 H-PGDS 的K_d值为 0.8 μM，IC₅₀值为 6 μM。对 COX-1，COX-2，m-PGES 或 L-PGDS 等无作用。

生物活性

HQL-79, a potent, selective and orally active humanhematopoietic prostaglandin D synthase (H-PGDS)inhibitor, highly selectively inhibits the synthesis of PGD₂, and acts as an anti-allergic agent, with aK_dof 0.8 μM and anIC₅₀of 6 μM. Shows no obvious effect onCOX-1,COX-2, m-PGES, or L-PGDS^[1].

IC₅₀& Target

IC50: 6 μM (H-PGDS)^[1]
Kd: 0.8 μM (H-PGDS)^[1]

体外研究
(In Vitro)

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH^[1].

分子量

377.48

性状

Solid

Formula

C₂₂H₂₇N₅O

CAS 号

162641-16-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month