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Penitrem A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Penitrem A图片
CAS NO:12627-35-9
包装与价格：
包装价格(元)
1mg询价
5mg询价
10mg询价

Penitrem A 是一种由青霉产生的吲哚二萜神经毒性生物碱，作为选择性 BK 通道拮抗剂，具有抗增殖和抗侵袭活性，可对抗多种恶性肿瘤。
Cas No.12627-35-9
别名青霉震颤素A
化学名(2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
Canonical SMILESClC1=C(C2)C3=C4C5=C([C@]([C@@H]([C@H]5OC(C)(C)[C@H]6[C@@]([C@@H](C2=C)C6)3O)CC7)(C)[C@@](CC8)(C)[C@]7([C@]9([C@H]8O[C@@H]%10C(C)=C)O[C@@H]9[C@H]%10O)O)NC4=C1
分子式C37H44ClNO6
分子量634.2
溶解度DMF: 20 mg/ml DMSO: 20 mg/ml DMSO:PBS(pH 7.2) (1:2): 30 mg/ml Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals[1][2].

References:
[1]. Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5).
[2]. Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34(1):33-42.

 
 
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