trans-Ned 19 是一种 NAADP 拮抗剂和 TPC 阻滞剂，可抑制人脐静脉内皮细胞 (HUVEC) 中的钙信号和响应低组胺浓度的大鼠主动脉松弛。
| Cas No. | 1354235-96-3 |
| 化学名 | (1R,3S)-1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid |
| Canonical SMILES | COC1=C(CN2CCN(C3=CC=CC=C3F)CC2)C=C([C@]4([H])C5=C(C6=CC=CC=C6N5)C[C@@](N4)([H])C(O)=O)C=C1 |
| 分子式 | C30H31FN4O3 |
| 分子量 | 514.59 |
| 溶解度 | DMF: 10 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1]. References:
[1]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438. |
