Reversin 121

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Reversin 121

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

174630-04-7

Reversin 121 是一种 P-糖蛋白 (P-glycoprotein) 抑制剂。Reversin 121 增加 MDR1 的 ATP 酶活性。Reversin 121 可逆转 P-糖蛋白介导的多药耐药性。Reversin 121 可用于癌症研究。

生物活性

Reversin 121 is aP-glycoproteininhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers^[1]^[2].

IC₅₀& Target

P-glycoprotein^[1]

体外研究
(In Vitro)

Reversin 121 (12 μg/mL) (withgemcitabine(HY-17026)) reduces the proportions of tumor cells positive for MDR proteins in Panc1 cell^[1].
Reversin 121 (5 μM) reverses the resistance against paclitaxel in paclitaxel-resistant NCI-H460 cell^[2].
Reversin 121 (10 μM, 48 h) inhibits T cell proliferation^[3].

体内研究
(In Vivo)

Reversin 121 (2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day, i.p.) decreases tumor size and prevalence of metastases^[1].

Animal Model:	Orthotopic pancreatic carcinoma mouse model^[1].
Dosage:	2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day
Administration:	Intraperitoneal injection (i.p.), 5 days a week
Result:	Decreased in MRP3-positive cells.

分子量

641.75

Formula

C₃₄H₄₇N₃O₉

CAS 号

174630-04-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.