MRS4596

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MRS4596

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

MRS4596 是一种有效的选择性 P2X4 受体 (P2X4 receptor) 拮抗剂，对人 P2X4 受体的IC₅₀为 1.38 μM。MRS4596 在缺血性脑卒中模型中具有神经保护和神经康复作用。MRS4596 可用于缺血性脑卒中研究。

生物活性

MRS4596 is a potent and selectiveP2X4 receptorantagonist with anIC₅₀value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke^[1].

IC₅₀& Target

IC₅₀: 1.38 μM (human P2X4 receptor)^[1]

体内研究
(In Vivo)

MRS4719 (compound 22c; 5 mg/kg; 3 days continuous infusion with an Alzet minipump) has neuroprotective and learning- and memory-enhancing activities in a mouse middle cerebral artery occlusion (MCAO) model of ischemic stroke^[1].

Animal Model:	Male and female young C57B/6 mice (8-12 weeks; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)^[1]
Dosage:	5 mg/kg
Administration:	3 days continuous infusion with an Alzet minipump
Result:	Decreased in total hemispheric infarct volume while effects were not significant on cortical or striatal infarct volume alone.

分子量

439.42

Formula

C₂₁H₁₄N₅NaO₃S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.