Thonzonium Bromide

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Thonzonium Bromide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

553-08-2

通佐溴胺

Thonzonium bromide，一种结构上与 Farnesol (HY-Y0248A) 相似的抗菌剂，是一种单阳离子表面活性剂，在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。Thonzonium bromide 以剂量依赖的方式抑制质子转运 (EC₅₀=69 μM)。

生物活性

Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC₅₀=69 μM)^[1]^[2]^[3].

体外研究
(In Vitro)

Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis^[1].

分子量

591.71

性状

Solid

Formula

C₃₂H₅₅BrN₄O

CAS 号

553-08-2

中文名称

通佐溴胺；嘧苯十六铵

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(169.00 mM;Need ultrasonic)

DMSO : ≥ 30 mg/mL(50.70 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.6900 mL	8.4501 mL	16.9002 mL
5 mM	0.3380 mL	1.6900 mL	3.3800 mL
10 mM	0.1690 mL	0.8450 mL	1.6900 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。