DHFR-IN-4

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DHFR-IN-4

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

DHFR-IN-4 是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂IC₅₀为 123 nM。DHFR-IN-4 对EGFR和HER2也具有抑制活性，IC₅₀分别为 246 nM 和 357 nM。DHFR-IN-4 对癌细胞具有显著的广谱细胞毒性活性。

生物活性

DHFR-IN-4 is a potentdihydrofolate reductase(DHFR) inhibitor with anIC₅₀value of 123 nM. DHFR-IN-4 also has inhibitory activity againstEGFRandHER2withIC₅₀s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency againstcancercells^[1].

IC₅₀& Target

IC₅₀: 123 nM (DHFR), 246 nM (EGFR), 357 nM (HER2)^[1]

体外研究
(In Vitro)

DHFR-IN-4 (compound 42) (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency against HepG2, MCF-7, HCT-116, PC3 and HeLa^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	HepG2, MCF-7, HCT-116, PC3 and HeLa
Concentration:	0-100 μM
Incubation Time:	72 h
Result:	Exhibited antiproliferative activity against HepG2, MCF-7, HCT-116, PC3 and HeLa with IC₅₀s of 9.67±0.7 μM, 8.46±0.7 μM, 13.24±0.9 μM, 11.17±1.0 μM and 6.90±0.5 μM.

分子量

371.46

Formula

C₁₈H₂₁N₅O₂S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.