MDL 101146

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MDL 101146

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

149859-17-6

MDL 101146 是一种中性粒细胞弹性蛋白酶抑制剂，具有口服活性。MDL 101146 抑制人类的中性粒细胞弹性蛋白酶，K_i值为 25 nM。MDL 101146 可用于关节炎的研究。

生物活性

MDL 101146 is an orally activeneutrophilelastaseinhibitor. MDL 101146 inhibits neutrophilelastasefor human with aK_ivalue of 25 nM. MDL 101146 can be used for the research of arthritis^[1]^[2].

IC₅₀& Target

Ki for neutrophil elastase: 25 nM (human); 18 nM (rat)^[1]^[2]

体外研究
(In Vitro)

MDL 101,146 inhibits human neutrophil elastase with a K_ivalue of 25 nM^[1].
MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a K_ivalue of 18 nM^[2].

体内研究
(In Vivo)

MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis^[2].

Animal Model:	Rats^[2]
Dosage:	200 mg/kg
Administration:	Oral, 200 mg/kg/day
Result:	Inhibited the severity of collagen-induced arthritis. Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.

分子量

632.62

Formula

C₂₉H₃₇F₅N₄O₆

CAS 号

149859-17-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.