Lonodelestat

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Lonodelestat

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

906547-89-5

POL6014

Lonodelestat (POL6014) 是有效的、具有口服活性的、选择性的人中性粒细胞弹性蛋白酶(hNE)的肽类抑制剂。Lonodelestat (POL6014) 具有囊性纤维化 (CF) 研究的潜力。

生物活性

Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor ofhuman neutrophilelastase(hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF)^[1]^[2]^[3].

体内研究
(In Vivo)

Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice^[1].
Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001)^[1].

Animal Model:	Ten-week-old male C57BL/6j mice^[1].
Dosage:	0.05, 0.2, 0.5 and 5 mg/kg.
Administration:	Administered intranasally (i.n.) 15 minutes before HNE (30 UI, i.n.).
Result:	Reduced the inflammatory processes of ALI in HNE treated mice.

Clinical Trial

分子量

1478.73

Formula

C₇₁H₁₁₁N₁₅O₁₉

CAS 号

906547-89-5

Sequence Shortening

cyclo[ASIPPQKYPPNle(bu)ET]

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.