ND-336 是基质金属蛋白酶 (MMP)-2、MMP-9 和 MMP-14 的选择性抑制剂，Kis 分别为 85、150 和 120 nM。
| Cas No. | 1807453-83-3 |
| Canonical SMILES | NCC(C=C1)=CC=C1OC2=CC=C(S(CC3SC3)(=O)=O)C=C2.Cl |
| 分子式 | C16H17NO3S2•HCl |
| 分子量 | 371.9 |
| 溶解度 | DMF: 5 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase-2 (MMP-2) and MMP-9, as well as MMP-14 (Kis = 85, 150, and 120 nM, respectively). It has minimal effect on other MMPs. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound. |
