Meclofenamic acid sodium hydrate

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CAS NO:

67254-91-5

Meclofenamate sodium hydrate

Meclofenamic acid (Meclofenamate) sodium hydrate 是一种非甾体抗炎剂。Meclofenamic acid sodium hydrate 是一种高选择性的脂肪和肥胖相关酶 (FTO) 抑制剂。Meclofenamic acid sodium hydrate 与 FTO 竞争，与含有 m(6)A 的核酸结合。Meclofenamic acid sodium hydrate 是一种非选择性的缝隙连接 (gap-junction) 阻滞剂。Meclofenamic acid sodium hydrate 抑制hKv2.1和hKv1.1，其IC₅₀分别为 56.0 和 155.9 μM。

生物活性

Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selectiveFTO(fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selectivegap-junctionblocker. Meclofenamic acid sodium hydrate inhibitshKv2.1andhKv1.1, withIC₅₀values of 56.0 and 155.9 μM, respectively^[1]^[2]^[3]^[4].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Meclofenamic acid sodium hydrate (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner^[1].
Meclofenamic acid sodium hydrate inhibits enzyme cyclooxygenase, with an IC₅₀about 1 μM, thereby inhibiting the production of prostaglandins^[2].
Meclofenamic acid sodium hydrate inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins^[2].

Western Blot Analysis^[1]

Cell Line:	HeLa cells
Concentration:	0, 12.5, 25, 50, 100 μM
Incubation Time:	24 h
Result:	Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.

Clinical Trial

分子量

336.15

Formula

C₁₄H₁₂Cl₂NNaO₃

CAS 号

67254-91-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.