M1002

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M1002

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	823830-85-9
包装:	5mg
市场价:	1300元

M1002 是一种缺氧诱导因子-2 (HIF-2) 激动剂，可以增强 HIF-2 靶基因的表达。M1002 与脯氨酰羟化酶结构域 (PHD) 抑制剂可发挥协同作用。

生物活性

M1002 is ahypoxia-inducible factor-2(HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors^[1].

体外研究
(In Vitro)

M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy^[1].
M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors^[1].

RT-PCR^[1]

Cell Line:	786-O cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control.

RT-PCR^[1]

Cell Line:	Hep3B cells
Concentration:	5 μM
Incubation Time:	24 hours
Result:	Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.

分子量

394.29

性状

Solid

Formula

C₁₅H₈F₆N₂O₂S

CAS 号

823830-85-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month