Nampt-IN-10 TFA

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Nampt-IN-10 TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2567724-20-1

Nampt-IN-10 TFA (compound 4) 是磷酸核糖转移酶(NAMPT)的抑制剂。Nampt-IN-10 TFA 对 A2780 和 CORL23 具有细胞效能，IC₅₀值分别为 5 和 19 nM。Nampt-IN-10 TFA 可以作为 ADCs 的非抗有丝分裂有效载荷。

生物活性

Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase(NAMPT)inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines withIC₅₀s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs^[1].

IC₅₀& Target

IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)^[1]

体外研究
(In Vitro)

Nampt-IN-10 TFA (0-1 μM; 72 h) shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines
Concentration:	0-1 μM
Incubation Time:	72 hours
Result:	Showed cellular potency towards A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC₅₀values of 5, 19, 2, 0.4 and 1 nM, respectively.

Formula

C₂₉H₂₉F₄N₅O₄

CAS 号

2567724-20-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.