UCD38B hydrochloride

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CAS NO:

1115177-19-9

UCD38B hydrochloride 是一种细胞渗透性、竞争性酶促uPA抑制剂，其IC₅₀值为 7 μM。UCD38B hydrochloride 靶向细胞内 uPA，导致 uPA 错误运输到核周线粒体中，降低线粒体膜电位，随后释放凋亡诱导因子 (AIF)。UCD38B hydrochloride 诱导细胞凋亡 (apoptosis)。

生物活性

UCD38B hydrochloride is a cell permeant, competitive enzymaticuPAinhibitor with anIC₅₀value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride inducesapoptosis^[1]^[2].

体外研究
(In Vitro)

UCD38B hydrochloride (10-250 μM; 1h) has cell permeant in U87MG cells^[1].
UCD38B hydrochloride (10-250 μM; 1h) inhibits cell growth with an IC₅₀value of 100 μM^[1].

Cell Viability Assay^[1]

Cell Line:	U87MG cells
Concentration:	10, 100, and 250 μM
Incubation Time:	24 hours
Result:	Inhibited cell growth in a dose-dependent manner.

Formula

C₁₅H₁₆ClN₇O₃.xHCl

CAS 号

1115177-19-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.