HKB99 是磷酸甘油酸突变酶 1 的变构抑制剂 (PGAM1)。HKB99 抑制侵袭性伪足的形成，提高 PAI-2 水平。HKB99 增加氧化应激，激活 JNK/c-Jun，抑制 AKT 和 ERK。HKB99 可用于非小细胞肺癌 (NSCLC) 的研究。
| 生物活性 | HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 inhibits the formation of invasive pseudopodia and increases the level of PAI-2 in vitro. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppressesAKTandERK. HKB99 can be used for the research of non-small-cell lungcancer(NSCLC)[1][2]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
