Alkannin

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Alkannin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

23444-65-7

Alkannin 是一种有效且特异性的肿瘤型丙酮酸激酶-M2 (PKM2) 抑制剂。Alkannin 不抑制 PKM1 和丙酮酸激酶-L (PKL)。Alkannin 可作于抗肿瘤的研究。

生物活性

Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent^[1].

体外研究
(In Vitro)

Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC₅₀of Alkannin is 0.3 μM. In the presence of FBP (125 μM), the IC₅₀of Alkannin is 0.9 μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2^[1].
Alkannin (2.5-20 μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption^[1].

Western Blot Analysis^[1]

Cell Line:	MCF-7 and A549 express PKM2 but not PKM1 and PKL
Concentration:	0-20 μM
Incubation Time:	1 hour
Result:	Inhibited the cellular glycolytic rate in a concentration-dependent manner.

分子量

288.30

Formula

C₁₆H₁₆O₅

CAS 号

23444-65-7

结构分类

Quinones
Naphthalene Quinones

Phenols
Monophenols

来源

Plants
Leguminosae
Ohwia caudata(Thunberg) H. Ohashi

Plants
Compositae

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.