Aliskiren fumarate is an orally active, highly potent and selectiverenininhibitor, withIC₅₀of 1.5 nM. Aliskiren fumarate can be used for the research of hypertension, cardiovascular diseases andcancercachexia^[1][2][3].

IC50: 1.5 nM (renin)^[1]

Aliskiren fumarate (< 10 mg/kg, Orally, daily) inhibits plasma renin activity and lowers blood pressure in sodium-depleted marmosets^[2].
Aliskiren fumarate (10 mg/kg, Intragastrically, once) significantly alleviates multiple cachexia-associated symptoms in BALB/c mice bearing C26 mouse colon carcinoma cells, including BW loss, tumor burden, muscle wasting, muscular dysfunction, and shortened survival^[3].

667.83

C₃₄H₅₇N₃O₁₀

1196835-68-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.