Enalkiren (A-64662) is a potentdipeptiderenininhibitor with anIC₅₀of 0.78 nM in a purified renal renin-angiotensinogen system (pH=6.0). Enalkiren suppressesreninactivity, and also reduces systolic and diastolic blood pressure. Enalkiren can be used to research essential hypertension^[1][2].

IC₅₀: 23 nM (hamster dipeptide renin), 14 nM (human dipeptide renin), 2.3 nM (cynomolgus monkey dipeptide renin)^[2]

Enalkiren inhibits the endogenous renin-angiotensinogen reaction with an IC₅₀value of 23 nM, 14 nM and 2.3 nM in hamster, human and cynomolgus monkey plasma, respectively, at pH 7.4^[2].

Enalkiren (0.01-10 mg/kg; i.v.; single dosage) reduces mean arterial blood pressure in cynomolgus monkey^[2].

656.86

C₃₅H₅₆N₆O₆

113082-98-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.