Zilovertamab

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Zilovertamab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

UC-961
Cirmtuzumab

Zilovertamab (UC-961) 是一种人源化抗ROR1单克隆抗体，可阻断 Wnt5a 诱导的 ROR1 信号通路。

生物活性

Zilovertamab (UC-961) is a humanised monoclonal antibody againstROR1that blocks Wnt5a-inducedROR1signalling^[1].

体外研究
(In Vitro)

Zilovertamab (25 and 50 μg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation^[1].
Zilovertamab (50 μg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level^[1].

Cell Proliferation Assay^[1]

Cell Line:	CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:	25 and 50 μg/mL
Incubation Time:	72 hours
Result:	Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis^[1]

Cell Line:	CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:	50 μg/mL
Incubation Time:	72 hours
Result:	Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.

Clinical Trial

性状

Liquid

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.