CVT-11127 是一种有效的SCD抑制剂。CVT-11127 诱导细胞凋亡apoposis并将细胞周期阻滞在 G1/S 期。 CVT-11127具有肺癌研究潜力。
| 生物活性 | CVT-11127 is a potentSCDinhibitor. CVT-11127 inducesapoposisand arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lungcancer[1]. |
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体外研究
(In Vitro) | CVT-11127 (1 μM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 μM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 μM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 μM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].
Cell Proliferation Assay[1] | Cell Line: | H460 cells | | Concentration: | 1 μM | | Incubation Time: | 48 h | | Result: | Showed antiproliferation activity. |
Cell Cycle Analysis[1] | Cell Line: | H460 cells | | Concentration: | 1 μM | | Incubation Time: | 48 h | | Result: | Decreased the the population of cells in S-phase by 75%. |
Apoptosis Analysis[1] | Cell Line: | H460 cells | | Concentration: | 1 μM | | Incubation Time: | 24 h | | Result: | Induced apoposis H460 cells. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : 25 mg/mL(48.79 mM;Need ultrasonic) 配制储备液 | 1 mM | 1.9516 mL | 9.7582 mL | 19.5164 mL | | 5 mM | 0.3903 mL | 1.9516 mL | 3.9033 mL | | 10 mM | 0.1952 mL | 0.9758 mL | 1.9516 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
