SCD1 inhibitor-3

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SCD1 inhibitor-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1282606-48-7

SCD1 inhibitor-3 是一种安全、有效的具有口服活性的SCD1抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病，以及皮肤病、痤疮、癌症等的研究。

生物活性

SCD1 inhibitor-3 is a safe, potent and orally activeSCD1inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne andcancer^[1].

IC₅₀& Target

SCD1^[1]

体内研究
(In Vivo)

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %^[1].
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index^[1].

Animal Model:	Lewis rats^[1]
Dosage:	5 mg/kg
Administration:	P.o.; 4 hours
Result:	Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.

Animal Model:	Lewis rats^[1]
Dosage:	2~10 mg/kg
Administration:	P.o.; 4 hours
Result:	A dose-responsive reduction of plasma triglycerides desaturation index.

分子量

393.37

性状

Solid

Formula

C₁₉H₁₆FN₇O₂

CAS 号

1282606-48-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 125 mg/mL(317.77 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.5421 mL	12.7107 mL	25.4214 mL
5 mM	0.5084 mL	2.5421 mL	5.0843 mL
10 mM	0.2542 mL	1.2711 mL	2.5421 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。