Hirudin

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Hirudin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

8001-27-2

Hirudin 是一种具有抗凝血特性的凝血酶抑制剂。Hirudin 具有较强的抗血栓、伤口修复、抗纤维化、抗肿瘤和抗高尿酸血症作用。Hirudin 还会影响糖尿病并发症、脑出血等。

生物活性

Hirudin is athrombininhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, andothers^[1].

体外研究
(In Vitro)

Hirudin 抑制凝血酶活性，剥夺凝血酶裂解纤维蛋白原的能力，阻止纤维蛋白的形成及内外凝血通路中纤维蛋白单体的交联聚合过程^[1]。
Hirudin 通过拮抗凝血酶，减少人微血管内皮细胞凋亡，抑制 p-JAK2 的表达^[1]。
Hirudin 抑制 VEGF-Notch 通路和人微血管内皮细胞增殖在高剂量时^[1]。
Hirudin (3-10 mg/mL) 可逆转 TGF-β1 引起的 HK-2 细胞异常增殖和纤维化^[1]。
Hirudin 剂量依赖性地抑制血管紧张素 II 诱导的心肌成纤维细胞，抑制氧化应激，调节纤维相关因子，抑制 ERK1/2 通路^[1]。

体内研究
(In Vivo)

Hirudin 增加大鼠随机皮瓣的生存能力，减少炎症反应^[1]。
Hirudin 促进激光手术后 SD 大鼠的创面愈合^[1]。
Hirudin (10 和 15 mg/kg；灌胃，每天 1 次，持续 21 天) 改善肾间质纤维化来减少肾小管损伤和炎症在单侧输尿管梗阻 (UUO) 小鼠模型中^[2]。

Animal Model:	Male balb/c mice with underwent unilateral ureteral ligation (UUO)^[2]
Dosage:	10 and 15 mg/kg
Administration:	Oral gavage; 10 and 15 mg/kg, once daily for 21 days
Result:	Reduced renal damages and suppressed the upregulation of α-SMA, collagen deposition in UUO mice. Increased the level of fibrosis (collagen-I, FN, α-SMA), N-cad, slug and E-cad in UUO mice. Decreased the level of IL-1β, IL-6 and TNF-α, apoptosis of renal tubular cells in UUO mice. Decreased the expression of inflammatory factors, the occurrence of EMT, the incidence of fibrosis and the apoptosis of TGF-β-induced renal tubular epithelial cell.

CAS 号

8001-27-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.