Allopurinol Sodium

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Allopurinol Sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

17795-21-0

别嘌醇钠

Allopurinol sodium 是一种有效的口服活性黄嘌呤氧化酶xanthine oxidase抑制剂，IC₅₀值为0.2-50 μM。Allopurinol sodium 可用于治疗高尿酸血症和痛风。Allopurinol sodium 降低 HIF-1α 和 HIF-2α 蛋白的表达。Allopurinol sodium 显示出抗抑郁和抗伤害活性。Allopurinol sodium 具有抗利什曼原虫作用。

生物活性

Allopurinol sodium is a potent and orally activexanthine oxidaseinhibitor with anIC₅₀value of 0.2-50 μM. Allopurinol sodium can be used in the treatment of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect^[1]^[2]^[3]^[4]^[5].

体外研究
(In Vitro)

Allopurinol sodium (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells^[5].
Allopurinol sodium (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells^[5].

Western Blot Analysis^[5]

Cell Line:	HFF, HUVEC cells
Concentration:	0, 10, 100, 1000 μg/ml
Incubation Time:	17 h
Result:	Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.

体内研究
(In Vivo)

Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse^[3].
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse^[4].

Animal Model:	20-30 g, male Swiss Albino mice^[3]
Dosage:	39 mg/kg
Administration:	P.o.; daily for 21 successive days
Result:	Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.

Animal Model:	30-40 g, male adult Swiss albino mice^[4]
Dosage:	10, 50, 100, 200, 400 mg/kg
Administration:	I.p.
Result:	Produced dose-dependent anti-nociception in the tail-flick, hot-plate.

Clinical Trial

分子量

160.11

Formula

C₅H₅N₄NaO

CAS 号

17795-21-0

中文名称

别嘌醇钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.