Benzalkonium chloride(Alkyldimethylbenzylammonium chloride)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	8001-54-5
包装:	1g
市场价:	446元

Benzalkonium chloride (Alkyldimethylbenzylammonium chloride) 是一种有效的抗微生物剂，用作滴眼液中的防腐剂。

Cas No.	8001-54-5
别名	苯扎氯铵; Alkyldimethylbenzylammonium chloride
Canonical SMILES	C[N+](C[(CH2)nCH3])(C)CC1=CC=CC=C1.[Cl-].[n=].[6 -16]
分子式	C₆H₅CH₂N(CH₃)₂RCl (R=C₈H₁₇to C₁₈H₃₇)
分子量	368.04
溶解度	DMSO : 50 mg/mL ;Water : ≥ 20 mg/mL
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Benzalkonium chloride is a potent anti-microbial agent, used as a preservative in eye drops. Benzalkonium chloride (0.0001%-0.5%) results in a dose-dependent cytotoxicity in cells. Benzalkonium chloride also shows cytotoxicity against human keratinocytes, with 50% loss of viability of 4 μM. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED50 of 3.9 and 62 μM, respectively. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1]. Benzalkonium chloride (0.02%) causes no abnormalities in the nasal epithelium of the monkeys after light and electron microscopical examination. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1]. [1]. Johnson NF. Pulmonary Toxicity of Benzalkonium Chloride. J Aerosol Med Pulm Drug Deliv. 2017 Jul 6.