(-)Clausenamide

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(-)Clausenamide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

201529-58-0

(-)(Clausenamide) 是从黄皮 (Clausena lansium (Lour) skeels) 的树叶中分离出来的一种活性生物碱，在正常生理和病理条件下提高认知功能。(-)Clausenamide 抑制 β-淀粉样蛋白 (Aβ) 毒性，通过抑制tau蛋白磷酸化阻止神经纤维缠结的形成。(-)Clausenamide 对 Aβ_25-35的刺激具有显著的神经保护作用。(-)Clausenamide 可用于阿尔兹海默症的研究。

生物活性	(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibitsβ-amyloid(Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation oftauprotein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ_25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD)^[1]^[2]^[3].
体外研究 (In Vitro)	(-)Clausenamide (10 and 100 μM) reverses the overload in [Ca²⁺]_ilevel stimulated by Aβ_25-35, and reduces Aβ-mediated cell apoptosis in PC12 cells^[3]. (-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK, down-regulates the expression of P53 and cleaved Caspase-3 and the ratio of Bax/Bcl-2, in Aβ_25-35-treated PC12 cells^[3].
分子量	297.35
Formula	C₁₈H₁₉NO₃
CAS 号	201529-58-0
结构分类	Alkaloids Other Alkaloids
来源	Plants Rutaceae Clausena lansium(Lour.) Skeels
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.