CAS NO: | 172889-26-8 |
生物活性 | PP1 is a potent, andSrcfamily-selective tyrosine kinase inhibitor withIC50of 5 and 6 nM for Lck and Fyn, respectively. | ||||||||||||||||
IC50& Target | IC50: 5 nM (Lck), 6 nM (Fyn), 250 nM (EGFR), >50 μM (JAK2)[1] | ||||||||||||||||
体外研究 (In Vitro) | PP1 inhibits Lck (IC50=5 nM) and FynT (IC50=6 nM) in vitro at concentrations significantly lower than those required to inhibit ZAP-70 (IC50>100 μM), JAK2 (IC50>50 μM), the EGFR kinase, and protein kinase A. PP1 inhibits whole cell tyrosine phosphorylation and proliferation in T cells stimulated with anti-CD3 and mitogens. PP1 selectively inhibits IL-2 gene expression over GM-CSF and IL-2R gene induction in human T cells[1]. | ||||||||||||||||
分子量 | 281.36 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H19N5 | ||||||||||||||||
CAS 号 | 172889-26-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 28 mg/mL(99.52 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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