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Hexanolamino PAF C-16
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hexanolamino PAF C-16图片
CAS NO:137566-83-7
包装与价格：
包装价格(元)
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a PAF analog with mixed agonist/antagonist properties
Cas No.137566-83-7
化学名1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl(N,N,N-trimethyl)hexanolamine
Canonical SMILESCCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCCCCCC[N+](C)(C)C)([O-])=O
分子式C30H62NO7P
分子量579.8
溶解度≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hexanolamino PAF C-16 is a PAF analog with PAF agonist/antagonist properties.

Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages [1].

Hexanolamino PAF C-16, a PAF analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. In human monocyte-derived macrophages, Hexanolamino PAF C-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (H202) in response to PAF [1]. In both rabbit platelets and guinea-pig macrophages, Hexanolamino PAF C-16 acted as a partial agonist [2].

References:
[1].  Rouis M, Nigon F, Chapman MJ. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun. 1988 Nov 15;156(3):1293-301.
[2].  Stewart AG, Grigoriadis G. Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat. 1991 Nov;4(3):299-308.

 
 
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