Compound C5-IN-1 (Compound 7) 是补体成分蛋白5 (C5) 的小分子抑制剂。Compound C5-IN-1 与 C5 相互作用以防止其被 C5 转化酶切割, 阻断酵母多糖诱导的 50％人全血 MAC 沉积的 IC50 值为 0.77 μM。
| Cas No. | 2365402-67-9 |
| Canonical SMILES | COC1=C(OCCCC(C)C)C=C(NC(N[C@H](C2=C(OC)C=CC=C2)C)=O)C(C(O)=O)=C1 |
| 分子式 | C24H32N2O6 |
| 分子量 | 444.52 |
| 溶解度 | DMSO: ≥ 100 mg/mL (224.96 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). Complement C5-IN-1 interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood with an IC50 of 0.77 µM[1]. [1]. Jendza K, et al. A small-molecule inhibitor of C5 complement protein. Nat Chem Biol. 2019 Jul;15(7):666-668. |
